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IPSS for MDS

International Prognostic Scoring System (Greenberg et al, 1997)
Risk assessment system to evaluate the prognosis of newly diagnosed MDS patients.

Risk group
Score
Median survival
Time to AML transformation
(years)
(for 25% in years)
Low risk
0
5.7
9.4
INT-1
0.5-1.0
3.5
3.3
INT-2
1.5-2.0
1.2
1.1
High risk
>2.5
0.4
0.2


Score value
Prognostic variable
0
0.5
1
1.5
2
BM blasts (%)
<5
5-10
-
11-20
21-30
Karyotype¤
Good
Intermed.
Poor
Cytopenias*
0/1
2/3

 




¤Good:normal,-Y,del(5q),del(20q). Poor:complex (>3 abnormalities) or chromosome 7 anomalies. Intermediate:other abnormalities.

*Hemoglobin <100 g/l, ANC <1.5 mia/l, platelets <100 mia/l.

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